Clonal Evolution During Stress Hematopoiesis
نویسندگان
چکیده
منابع مشابه
Chipping in on clonal hematopoiesis
Myeloid neoplasms are clonal diseases of hematopoietic stem or progenitor cells that result from molecular alterations that perturb cellular self-renewal, proliferation, and differentiation. As classified by the World Health Organization, myeloid neoplasms include myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), MPN/MDS overlap, and acute myeloid leukemia (AML), which can oc...
متن کاملClonal Hematopoiesis in Aplastic Anemia
WENTY-FIVE YEARS AGO, William Dameshek, T the founder of this journal and one of the most creative minds in American hematology, raised a provocative question: what do aplastic anemia (AA), paroxysmal nocturnal hemoglobinuria (PNH), and acute leukemia have in common?’ His question was prompted by three observations: (1) the frequency of development of PNH in his own patients with AA, (2) the ov...
متن کاملEvolution of resistance during clonal expansion.
Acquired drug resistance is a major limitation for cancer therapy. Often, one genetic alteration suffices to confer resistance to an otherwise successful therapy. However, little is known about the dynamics of the emergence of resistant tumor cells. In this article, we consider an exponentially growing population starting from one cancer cell that is sensitive to therapy. Sensitive cancer cells...
متن کاملClonal hematopoiesis in acquired aplastic anemia.
Clonal hematopoiesis (CH) in aplastic anemia (AA) has been closely linked to the evolution of late clonal disorders, including paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), which are common complications after successful immunosuppressive therapy (IST). With the advent of high-throughput sequencing of recent years, the molecular aspect of ...
متن کاملThe NFKB Inducing Kinase Modulates Hematopoiesis During Stress.
The genetic programs that maintain hematopoiesis during steady state in physiologic conditions are different from those activated during stress. Here, we show that hematopoietic stem cells (HSCs) with deficiencies in components of the alternative NFκB pathway (the NFκB inducing kinase, NIK, and the downstream molecule NFκB2) had a defect in response to stressors such as supraphysiological doses...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2017
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v130.suppl_1.sci-38.sci-38